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Central Nervous System

Preclinical

Phase I

Phase II

Phase III

TNX-102 SL   Major Depressive Disorder
Phase 2 study planned 2H’26

Phase II Ready

TNX-102 SL   Acute Stress Disorder/Acute Stress Reaction
Investigator-Initiated Study
Phase 2 topline data planned 2H’26

Phase II

TNX-1300   Cocaine Intoxication
Mid-Phase 2

Phase II Ready

Infectious Disease

Preclinical

Phase I

Phase II

Phase III

TNX-4800   Prevention of Lyme Disease in the U.S.
Adaptive Phase 2 field study planned 1H’27 pending FDA agreement

Phase II

TNX-801   Prevention of Smallpox and Mpox
Preclinical

Preclinical

TNX-4200   Protect Against Viral Diseases
Preclinical
Anti-CD40 ligand mAb

Preclinical

Immunology and Immuno-oncology

Preclinical

Phase I

Phase II

Phase III

TNX-1500   Prevention of Organ Transplant Rejection
Investigator-Initiated study
Phase 2 study planned 2H’26

Preclinical

TNX-1700   Gastric and Colorectal Cancer
Preclinical

Preclinical

TNX-4700   Immuno-oncology Indications
Preclinical

Preclinical

Rare Disease

Preclinical

Phase I

Phase II

Phase III

TNX-2900   Prader-Willi Syndrome
FDA Orphan Drug and Rare Pediatric Disease Designation
Phase 2 study planned 1Q’27

Phase II Ready