Tonix Pharmaceuticals is currently recruiting participants in a Phase 3 trial for military-related posttraumatic stress disorder.  For more information, please visit www.thehonorstudy.com or www.clinicaltrials.gov (NCT03062540).

Research & Development : Scientific Presentations

Scientific Presentations

A Randomized Placebo-Controlled Multicenter Trial of a Low-Dose Bedtime Sublingual Formulation of Cyclobenzaprine (TNX-102 SL) for the Treatment of Military-Related PTSD

Poster Presentation at the American Society of Clinical Psychopharmacology 2016 Annual Meeting in Scottsdale AZ June 1, 2016

Sullivan GM, Gendreau JF, Gendreau RM, Schaberg A, Daugherty BL, Jividen H, Peters A, Peters P, Lederman S. A Randomized Placebo-Controlled Multicenter Trial of a Low-Dose Bedtime Sublingual Formulation of Cyclobenzaprine (TNX-102 SL) for the Treatment of Military-Related PTSD. Poster session presented at: American Society of Clinical Psychopharmacology (ASCP) 2016 Annual Meeting. 2016 May 30 - Jun 3; Scottsdale, AZ.

Uploaded: May 31, 2016
Type: Pdf

A Randomized Placebo-Controlled Multicenter Trial of a Low-Dose Bedtime Sublingual Formulation of Cyclobenzaprine (TNX-102 SL) for the Treatment of Military-Related PTSD

Oral Presentation at the American Society of Clinical Psychopharmacology, Annual Meeting, Scottsdale AZ May 31, 2016

Sullivan G. A Randomized Placebo-Controlled Multicenter Trial of a Low-Dose Bedtime Sublingual Formulation of Cyclobenzaprine (TNX-102 SL) for the Treatment of Military-Related PTSD. Oral presentation presented at: American Society of Clinical Psychopharmacology (ASCP) 2016 Annual Meeting. 2016 May 30 - Jun 3; Scottsdale, AZ.

Uploaded: May 31, 2016
Type: Pdf

Rapid Sublingual Absorption of Cyclobenzaprine (CBP) with Basifying Agents: Prospect for Bedtime Treatment of Fibromyalgia Syndrome (FM) Presentation Number: LB-026

Poster Presentation at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2016 Annual Meeting in San Diego, CA

Daugherty B, Monti NC, Panzeri V, Marelli R, Magnocavallo E, Reiner G, Lederman S. Rapid Sublingual Absorption of Cyclobenzaprine (CBP) with Basifying Agents: Prospect for Bedtime Treatment of Fibromyalgia Syndrome (FM). Poster session presented at: American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2016 Annual Meeting. 2016 Mar 8-12; San Diego, CA.

Uploaded: Mar 9, 2016
Type: Pdf

Comparative Neuropharmacology of Therapeutic Agents Targeting Posttraumatic Stress Disorder

Poster Presentaiton at the NEI Psychopharmacology Congress in November 2015.

Bruce L. Daugherty, Gregory M. Sullivan, Leland Gershell, Seth Lederman

Uploaded: Nov 13, 2015
Type: Pdf

An Evaluation of the Ef cacy of a Low Dose, Bedtime, Sublingual Formulation of Cyclobenzaprine (TNX-102 SL) in Military-Related PTSD

Poster Presentation at the NEI Psychopharmacology Congress in November 2015.

Gregory M. Sullivan, Judy F. Gendreau, R. Michael Gendreau, Amy Schaberg, Bruce L. Daugherty, Heather Jividen, Ashild Peters, Perry Peters, Seth Lederman

Uploaded: Nov 13, 2015
Type: Pdf

Bedtime, Rapidly Absorbed Sublingual Cyclobenzaprine (TNX-102 SL) for the Treatment of Fibromyalgia: Results of a Phase 2b Randomized, Double-Blind, Placebo-Controlled Study

Poster Presentation at the American College of Rheumatology (ACR) 2015 Annual Meeting in San Francisco, CA

Lederman S, Gendreau RM, Clauw DJ, Arnold LM, Gendreau J, Daugherty B, Forst A. Bedtime, Rapidly Absorbed Sublingual Cyclobenzaprine (TNX-102 SL) for the Treatment of Fibromyalgia: Results of a Phase 2b Randomized, Double-Blind, Placebo-Controlled Study [abstract]. Arthritis Rheumatol. 2015; 67 (Suppl 10).

Uploaded: Nov 10, 2015
Type: Pdf

Relationship of Sleep Quality and Fibromyalgia Outcomes in a Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study of Bedtime, Rapidly Absorbed, Sublingual Cyclobenzaprine (TNX-102 SL)

Poster Presentation at the American College of Rheumatology (ACR) 2015 Annual Meeting in San Francisco, CA

Moldofsky H, Gendreau RM, Clauw DJ, Gendreau J, Vaughn B, Daugherty B, Forst A, Sullivan G, Lederman S. Relationship of Sleep Quality and Fibromyalgia Outcomes in a Phase 2b Randomized, Double-Blind, Placebo-Controlled Study of Bedtime, Rapidly Absorbed, Sublingual Cyclobenzaprine (TNX-102 SL) [abstract]. Arthritis Rheumatol. 2015; 67 (Suppl 10).

Uploaded: Nov 10, 2015
Type: Pdf

Responder Compared to Mean Change Analyses in a Fibromyalgia Phase 2b Clinical Study of Bedtime Rapidly Absorbed Sublingual Cyclobenzaprine (TNX-102 SL)

Poster Presentation at the American College of Rheumatology (ACR) 2015 Annual Meeting in San Francisco, CA

Gendreau RM, Clauw DJ, Gendreau J, Daugherty B, Lederman S. Responder Compared to Mean Change Analyses in a Fibromyalgia Phase 2b Clinical Study of Bedtime Rapidly Absorbed Sublingual Cyclobenzaprine (TNX-102 SL) [abstract]. Arthritis Rheumatol. 2015; 67 (Suppl 10).

Uploaded: Nov 10, 2015
Type: Pdf

The AtEase Study: An Evaluation of the Efficacy of a Low Dose, Bedtime, Sublingual Formulation of Cyclobenzaprine (TNX-102 SL) for the Treatment of Military-Related PTSD

Poster Presentation at the Military Health System Research Symposium (MHSRS) 2015 Annual Meeting in Fort Lauderdale, FL

Sullivan GM, Gendreau JF, Gendreau RM, Schaberg A, Daugherty BL, Jividen H, Peters A, Peters P, Lederman S. The AtEase Study: An Evaluation of the Efficacy of a Low Dose, Bedtime, Sublingual Formulation of Cyclobenzaprine (TNX-102 SL) for the Treatment of Military-Related PTSD. Poster session presented at: 2015 Military Health System Research Symposium (MHSRS); 2015 Aug 17-21; Ft. Lauderdale, FL.

Uploaded: Aug 18, 2015
Type: Pdf

(R)-isometheptene* (IMH) Binds to the Imidazoline-1 Receptor and (S)-IMH increases Blood Pressure: Potentially Superior Benefit-to-Risk Ratio for (R)-IMH as an Analgesic for Headache

Poster Presentation at the American Headache Society (AHS) 2015 Annual Meeting in Washington, DC

Daugherty B, Gershell L, Lederman S. (R)-Isometheptene (IMH)* Binds to the Imidazole-1 Receptor and (S)-IMH Increases Blood Pressure: Potentially Superior Benefit to Risk Ratio for (R)-IMH as an Analgesic for Headache. Headache. 2015; 55: 172.

Uploaded: Jun 22, 2015
Type: Pdf